The pioneer for GDF-15
targeting in immuno-oncology
CatalYm has identified GDF-15 as a key regulator of the immune system in the tumor microenvironment. We are pioneering the reversal of GDF-15-mediated immunosuppression to induce a potent antitumoral immune reaction in nonresponsive tumors.
CatalYm’s lead program, CTL-002, is poised to demonstrate clinical proof-of-concept in multiple solid tumor indications and has the potential to expand the treatment horizon for current and future immunotherapies.
Phil L’HuillierPhD, MBA Managing Director and
Chief Executive Officer (CEO)
Phil L’Huillier serves as Managing Director and Chief Executive Officer at CatalYm. He brings over two decades of experience in executive leadership positions in the pharmaceutical and biotechnology industries, with an outstanding track record of success in the commercial development of businesses and partnerships. Prior to joining CatalYm, he served as Head of the European Innovation Hub & Business Development at MSD (known as Merck & Co. in North America). In this role, he was an active member of MSD’s global Business Development and Licensing Leadership and led a team of scientific and business development professionals. Phil worked for a decade as Executive Director and Board Member of Cancer Research Technology, where he was responsible for development, commercialization and licensing of numerous programs, from discovery to early clinical stages. He simultaneously played key roles in the formation of a number of biotech companies and served as Non-Executive Director for Achilles Therapeutics, Artios Pharma, BliNK Therapeutics, PsiOxus Therapeutics and Revitope Therapeutics. Phil holds a PhD in cellular and molecular biology from the University of Auckland, New Zealand, as well as an MBA.
Chief Executive Officer (CEO)
Christine Schuberth-WagnerPhD, MBA Chief Scientific Officer (CSO)
Christine Schuberth-Wagner serves as Chief Scientific Officer at CatalYm. She joined the company in November 2018 with more than 10 years of experience in drug discovery and non-clinical development of immunomodulatory drugs in the immuno-oncology space. She has established a track record as a successful leader and entrepreneur in the biotech industry. Prior to joining CatalYm, Christine co-founded Rigontec in 2014 where she led the company’s discovery and non-clinical development activities as Senior Vice President, Research. Her discoveries on the first-in-class RNA-based innate immune receptor agonist RGT100, built the foundation for the initiation of a Phase I clinical trial as well as the successful acquisition of Rigontec by MSD (known as Merck & Co. in North America) in late 2017. Christine holds a PhD in Molecular Biomedicine from the University of Bonn and an MBA from the University of Potsdam.
Eugen LeoMD, PhD, MBA Chief Medical Officer (CMO)
Eugen Leo serves as Chief Medical Officer at CatalYm. Prior, he served as CMO for Rigontec, where he helped facilitate the company’s acquisition by MSD (known as Merck & Co. in North America). Eugen brings more than 20 years of experience in industrial phase I-III development of targeted molecules in the immuno-oncology space, ranging from kinase inhibitors, antibodies and antibody derivatives to vaccines, antisense molecules and cell therapies. His contributions were instrumental in reaching proof-of-concept for the BiTE (bi-specific T-cell engager) antibody platform, ultimately leading to Micromet’s acquisition by Amgen in 2012, as well as for the development of various other first-in-class molecules in the immuno-oncology space. Previously, he served in various positions with increasing levels of responsibility in both biotech (e.g. Micromet, Oxford Biotherapeutics, Ambit Biosciences, Isarna Therapeutics) and large pharmaceutical companies (Johnson & Johnson, Merck-Serono). Eugen is a board-certified Hematologist and Medical Oncologist and holds an Associate Professorship at the University of Heidelberg. He studied medicine at the Universities of Freiburg, Cincinnati and Münster and obtained an MBA from Colorado State University.
Anne BurgerChief Financial Officer (CFO)
Anne Burger serves as Chief Financial Officer at CatalYm. She brings more than 15 years of experience in financial operations at biotech and medtech companies throughout Europe. She also served as the CFO and Co-Founder of Breath Therapeutics GmbH, where she was instrumental in securing the financing (EUR 43.5million) as well as executing the sale of the company to Zambon S.p.A. in 2019, with a deal value up to EUR 500 million. Previously, Anne served as CFO at Rigontec and had an active role in the execution of Rigontec’s trade sale to MSD (known as Merck & Co. in North America), a deal worth up to EUR 464 million. Throughout her career, Anne has been responsible for corporate fundraising, executing trade sales and licensing agreements, and preparing for IPOs in several senior executive and advisory roles in the life sciences industry. Anne holds a graduate degree in Business Administration from Ludwig-Maximilians-University in Munich and has completed graduate studies in public health.
Board of Directors
John HaurumPhD, MBA Chairman
John Haurum serves as the Chairman of the Board of Directors at CatalYm. In addition, John is a non-executive director of Agomab, Neophore, Synact, SynKlino and Storm. Previously, John served as CEO of F-star Therapeutics in Cambridge, England, and held the position of Vice President, Research at ImClone Systems. He also co-founded and served as the CSO of Symphogen, Denmark. He holds a D.Phil. in Immunology from The University of Oxford and an MD from Aarhus University, Denmark.
Hans van EenennaamPhD Independent member
Hans van Eenennaam most recently served as Chief Scientific Officer of AIMM Therapeutics and up until March 2019, as Executive Vice President of Antibody Research and Site Head for Aduro Biotech Europe. In 2015, Aduro acquired BioNovion, a company advancing novel antibody therapies for immuno- oncology, which van Eenennaam co-founded in 2011 and also served as its Chief Operational Officer. He also serves on the Board of Directors of Lygature. Dr. van Eenennaam received his doctorate in autoimmune biochemistry from Radboud University in Nijmegen, Netherlands.
Marc LohrmannBoard member
Marc Lohrmann is Managing Partner at Vesalius Biocapital III. He has over 20 years of experience and joined Vesalius Biocapital in 2012 as a venture partner and became a Managing Partner in 2017. Marc co-founded Reverse Medical (acquired by Covidien in 2014), was an investment manager at Bayer Innovation and worked with several corporate finance boutique firms focused on M&A transactions in the life sciences space. He holds a diploma degree in Business Administration of the University of Stuttgart-Hohenheim.
Rogier RooswinkelPhD Board member
Rogier Rooswinkel is Partner at Forbion where he is responsible for evaluation and structuring of new investment opportunities across all disease areas with an emphasis on oncology. He currently serves as a board member of Achilles and as a board observer for Enterprise, Prilenia and Escalier. Prior to joining Forbion, Rogier worked as a post-doc in immunology at the Netherlands Cancer Institute. Rogier holds a PhD from the University of Amsterdam and a master’s degree in Oncology from the VU University of Amsterdam.
Oskar SlotboomBoard member
Oskar Slotboom joined BioGeneration Ventures as a partner in 2016, strengthening the team with his commercial, business development and consulting experience. Oskar started his career in McKinsey & Company as a management consultant. After that he held positions in Crucell, first as Business Development Director and later he became responsible for its pediatric franchise. After the acquisition of Crucell by Johnson & Johnson, Oskar led the Vaccines & Infectious Diseases business unit in Johnson & Johnson’s pharma joint venture, Xian Janssen, in Beijing, China. Oskar holds a degree in chemical engineering from the Twente University and holds an MBA from INSEAD.
Marianne UtengPhD Board member
Marianne Uteng is a Principal at the Novartis Venture Fund (NVF) in Basel, Switzerland. Prior to joining NVF, she worked at Novartis Global Drug Development and, before that, in the Pre-Clinical Safety Department at the Novartis Institutes of Biomedical Research, where she led teams delivering health authority-required and non-routine safety assessments for early and late-stage programs across many therapeutic areas. Concurrently, she supported the Novartis BD&L Search & Evaluation Team and spearheaded collaborations with biotechnology companies and academia for development of innovative in vitro/in vivo systems. Marianne received her MSc in Biochemistry from the University of Oslo and her PhD in Molecular Biology, Cell Biology and Biophysics from a joint program between European Molecular Biology Laboratories and the University of Oslo.
Nathalie WeitemeyerBoard member
Nathalie Weitemeyer is senior investment manager at Bayern Kapital, the venture capital organisation of the Free State of Bavaria. She works on various projects in life science, computer science, engineering and in the energy sector. She started her career as a scientist for a biotech-start-up company in the field of drug carrier systems. Nathalie holds a PhD in Chemistry from the Eberhard-Karl-University in Tübingen and a degree in Economics (Dipl. Wirtschafts-Chemikerin) from Fern-Universität Hagen.