GDFATHER-01 Trial Long Term Follow-Up: GDF-15 Neutralization Combined With Nivolumab Can Enable Deep, Long-Term Remission In Heavily Pretreated, Anti-PD1/-L1 Relapsed/ Refractory Major Solid Tumor Types
Ignacio Melero Bermejo, María de Miguel Luken, Elena Garralda Cabanas, Guillermo de...
Read MoreGDF-15 blockade: A multi-directional approach to potentiate cancer immunotherapy and alleviate cancer cachexia
Ignacio Melero, Kathrin Klar, Eugen Leo / Clin Transl Med. 2025; 15:e70280.
Read MoreNeutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours
Ignacio Melero, Maria de Miguel Luken, Guillermo de Velasco, Elena Garralda, Juan...
Read MoreGDF-15 neutralizing antibody visugromab increases intratumoral immune cell infiltration to support bispecific T-cell engagers
Sabrina Genssler, Daniel Schaetzlein, Eugen Leo, Markus Haake and Christine Schuberth-Wagner /...
Read MoreSHP-1 is a central mediator of GDF-15 mediated adhesion inhibition in T-cells
Markus Haake, Neha Vashist, Beatrice Haack, Birgitt Fischer, Kristin Eichler, Matthias Kist,...
Read More12P Immuno-suppressive role of tumour-derived GDF-15 on myeloid cells
Schuberth-Wagner, C., Giese, I., Kist, M., Vashist, N., Genßler, S., Haack, B.,...
Read MoreCancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance
Interview with Christine Schuberth-Wagner, Chief Scientific Officer at CatalYm / Drug Target...
Read MoreTumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment
Markus Haake, Beatrice Haack, Tina Schäfer, Patrick N. Harter, Greta Mattavelli, Patrick...
Read MoreTumor-derived GDF-15 prevents therapy success of checkpoint inhibitors by blocking T-lymphocyte recruitment
Markus Haake, Tina Schäfer, Beatrice Haack, Neha Vashist, Sabrina Genßler, Patrick Harter,...
Read MoreA phase I, first-in-human clinical trial of the GDF-15 neutralizing antibody CTL-002 in subjects with advanced stage solid tumors (Acronym: GDFATHER)
Ignacio Melero, Emiliano Calvo, Maria-Elisabeth Goebeler, Elena Garralda, Reinhard Dummer, María Rodríguez-Ruiz,...
Read MoreTumor-derived GDF-15 to suppress T-lymphocyte recruitment to the tumor microenvironment resulting in resistance to ANTI-PD-1 treatment.
Joerg Wischhusen, Markus Haake, Neha Vashist, Sabrina Genßler, Kilian Wistuba-Hamprecht, Patrick Harter,...
Read MoreColchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation
Jui-Hsia Weng, Peter David Koch, Harding H. Luan, Ho-Chou Tu, Kenichi Shimada,...
Read MoreGDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma
Zhaowei Wang, Lei He, Weina Li, Chuanyang Xu, Jieyu Zhang, Desheng Wang,...
Read MoreTumor-derived GDF-15 suppresses T-lymphocyte recruitment to the tumor microenvironment
Markus Haake, Neha Vashist, Sabrina Genssler, Kristin H. Eichler, Birgitt Fischer, Jessica...
Read MoreGrowth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint
Joerg Wischhusen J, Ignacio Melero,Wolf Herman Fridman Front Immunol. 2020 May 19;11:951....
Read MoreCirculating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation
Holger Kleinertz, Monika Hepner-Schefczyk, Sabrina Ehnert, Maren Claus, Rebecca Halbgebauer, Lea Boller,...
Read MoreHigh GDF-15 Serum Levels Independently Correlate with Poorer Overall Survival of Patients with Tumor-Free Stage III and Unresectable Stage IV Melanoma
BenjaminWeide, Tina Schäfer, Alexander Martens, Anastasia Kuzkina, Laura Uder, Seema Noor, Claus...
Read MoreGDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice
Tibor Kempf, Alexander Zarbock, Christian Widera, Stefan Butz, Anika Stadtmann, Jan Rossaint...
Read MoreGDF-15 contributes to proliferation and immune escape of malignant gliomas
P. Roth, M. Junker, I. Tritschler, M. Mittelbronn, Y. Dombrowski, S. N....
Read MoreMIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma
D. A. Brown, R. L. Ward, P. Buckhaults, T. Liu, K. E....
Read MoreMIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily
M. R. Bootcov, A. R. Bauskin, S. M. Valenzuela, A. G. Moore,...
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