catalym
Posted by catalym
November 15, 2021
November 15, 2021

Tumor-derived GDF-15 prevents therapy success of checkpoint inhibitors by blocking T-lymphocyte recruitment

Markus Haake, Tina Schäfer, Beatrice Haack, Neha Vashist, Sabrina Genßler, Patrick Harter,...

Read More
catalym
Posted by catalym
November 15, 2021
November 15, 2021

A phase I, first-in-human clinical trial of the GDF-15 neutralizing antibody CTL-002 in subjects with advanced stage solid tumors (Acronym: GDFATHER)

Ignacio Melero, Emiliano Calvo, Maria-Elisabeth Goebeler, Elena Garralda, Reinhard Dummer, María Rodríguez-Ruiz,...

Read More
piomat
Posted by piomat
August 30, 2021
August 30, 2021

Tumor-derived GDF-15 to suppress T-lymphocyte recruitment to the tumor microenvironment resulting in resistance to ANTI-PD-1 treatment.

Joerg Wischhusen, Markus Haake, Neha Vashist, Sabrina Genßler, Kilian Wistuba-Hamprecht, Patrick Harter,...

Read More
piomat
Posted by piomat
August 30, 2021
August 30, 2021

Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activation

Jui-Hsia Weng, Peter David Koch, Harding H. Luan, Ho-Chou Tu, Kenichi Shimada,...

Read More
piomat
Posted by piomat
August 30, 2021
August 30, 2021

GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma

Zhaowei Wang, Lei He, Weina Li, Chuanyang Xu, Jieyu Zhang, Desheng Wang,...

Read More
piomat
Posted by piomat
August 30, 2021
August 30, 2021

Tumor-derived GDF-15 suppresses T-lymphocyte recruitment to the tumor microenvironment

Markus Haake, Neha Vashist, Sabrina Genssler, Kristin H. Eichler, Birgitt Fischer, Jessica...

Read More
ante
Posted by ante
August 29, 2021
August 29, 2021

Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint

Joerg Wischhusen J, Ignacio Melero,Wolf Herman Fridman Front Immunol. 2020 May 19;11:951....

Read More
ante
Posted by ante
August 28, 2021
August 28, 2021

Circulating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation

Holger Kleinertz, Monika Hepner-Schefczyk, Sabrina Ehnert, Maren Claus, Rebecca Halbgebauer, Lea Boller,...

Read More
ante
Posted by ante
August 27, 2021
August 27, 2021

High GDF-15 Serum Levels Independently Correlate with Poorer Overall Survival of Patients with Tumor-Free Stage III and Unresectable Stage IV Melanoma

BenjaminWeide, Tina Schäfer, Alexander Martens, Anastasia Kuzkina, Laura Uder, Seema Noor, Claus...

Read More
ante
Posted by ante
August 26, 2021
August 26, 2021

GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice

Tibor Kempf, Alexander Zarbock, Christian Widera, Stefan Butz, Anika Stadtmann, Jan Rossaint...

Read More