GDF-15 blockade: A multi-directional approach to potentiate cancer immunotherapy and alleviate cancer cachexia
Ignacio Melero, Kathrin Klar, Eugen Leo / Clin Transl Med. 2025; 15:e70280.
Read MoreNeutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours
Ignacio Melero, Maria de Miguel Luken, Guillermo de Velasco, Elena Garralda, Juan...
Read MoreGDF-15 neutralizing antibody visugromab increases intratumoral immune cell infiltration to support bispecific T-cell engagers
Sabrina Genssler, Daniel Schaetzlein, Eugen Leo, Markus Haake and Christine Schuberth-Wagner /...
Read MoreSHP-1 is a central mediator of GDF-15 mediated adhesion inhibition in T-cells
Markus Haake, Neha Vashist, Beatrice Haack, Birgitt Fischer, Kristin Eichler, Matthias Kist,...
Read More12P Immuno-suppressive role of tumour-derived GDF-15 on myeloid cells
Schuberth-Wagner, C., Giese, I., Kist, M., Vashist, N., Genßler, S., Haack, B.,...
Read MoreCancer immunotherapy: GDF-15’s role in Anti-PD-1 resistance
Interview with Christine Schuberth-Wagner, Chief Scientific Officer at CatalYm / Drug Target...
Read MoreTumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment
Markus Haake, Beatrice Haack, Tina Schäfer, Patrick N. Harter, Greta Mattavelli, Patrick...
Read MoreTumor-derived GDF-15 prevents therapy success of checkpoint inhibitors by blocking T-lymphocyte recruitment
Markus Haake, Tina Schäfer, Beatrice Haack, Neha Vashist, Sabrina Genßler, Patrick Harter,...
Read MoreA phase I, first-in-human clinical trial of the GDF-15 neutralizing antibody CTL-002 in subjects with advanced stage solid tumors (Acronym: GDFATHER)
Ignacio Melero, Emiliano Calvo, Maria-Elisabeth Goebeler, Elena Garralda, Reinhard Dummer, María Rodríguez-Ruiz,...
Read MoreTumor-derived GDF-15 to suppress T-lymphocyte recruitment to the tumor microenvironment resulting in resistance to ANTI-PD-1 treatment.
Joerg Wischhusen, Markus Haake, Neha Vashist, Sabrina Genßler, Kilian Wistuba-Hamprecht, Patrick Harter,...
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